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It leads to selective nerve signaling to the penile tissue, which stimulates nitric oxide release and promotes penile smooth muscle relaxation, vasodilation, and engorgement of the genital tissue. The central nervous system action may produce additional benefits

Lyophilization (freeze-drying) removes water from the peptide solution under vacuum

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However, a set of challenges impede delivering peptides to the brain, including low metabolic stability and poor penetration of the blood-brain barrier

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